4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde synthesis
- Product Name:4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde
- CAS Number:148256-82-0
- Molecular formula:C6H5ClN2OS
- Molecular Weight:188.63
1044145-59-6
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$82.00/100mg
148256-82-0
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$90.00/100mg
Yield:148256-82-0 96.4%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 28; for 12 h;
Steps:
Synthesis of 4-chloro-2-(methylthio)pyrimidine-5-carbaldehyde 3
Add (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol 2 (15.0 g, 78.7 mmol), activated MnO2 (20.0 g, 230.0 mmol) and 100 mL dichloromethane to a 150 mL single-neck flask , 28°C 12 h, TLC monitors the complete reaction of the raw materials (ethyl acetate: petroleum ether = 1:10), the reaction solution is filtered through diatomaceous earth to obtain the mother liquor, the mother liquor is dried by adding a small amount of anhydrous sodium sulfate, and the solvent is removed under reduced pressure , Placed in a vacuum desiccator overnight to obtain 14.3 g of compound 3 as a pale yellow solid, with a yield of 96.4%.
References:
Hunan Normal University;Xu Guangyu;Lin Zhaoji;Tian Shaixiao;Li Huiliang CN112142733, 2020, A Location in patent:Paragraph 0008
74840-34-9
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148256-82-0
108 suppliers
$90.00/100mg
5909-24-0
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$6.00/5g
148256-82-0
108 suppliers
$90.00/100mg