4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE synthesis
- Product Name:4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE
- CAS Number:85386-80-7
- Molecular formula:C9H5ClF3N
- Molecular Weight:219.59
Yield:85386-80-7 90%
Reaction Conditions:
in N,N-dimethyl-formamide at 130; for 8 h;
Steps:
2.2B
(2B) In a four-mouth bottle of 2L, sequentially added to obtain formula (IV) shown compound 23g (0.1mol, 98wt%), 100mL DMF and 5.9g sodium cyanide, 130 ° C after the cyanidation reaction for 8h, HPLC monitoring the end of the reaction; solvent removal, to the reaction system added 200mL of DCE, 10wt% sodium hydroxide solution to adjust pH to 7, stand layered, remove organic solvents, to give formula (V) The compound shown is 20.1 g , with a purity of 98% by weight and a yield of 90%. where, in equation (V), X = Cl.
References:
CN114573432,2022,A Location in patent:Paragraph 0087; 0089
1839-92-5
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