4-CHLORO-3',5'-DIMETHYLBENZOPHENONE synthesis

Yield:844885-03-6 86%

Reaction Conditions:

with aluminum (III) chloride at 20 - 70; for 16 h;

Steps:

4.1 (1)
Synthesis of 3',5'-dimethyl-4-chloro benzophenone

(1)
Synthesis of 3',5'-dimethyl-4-chloro benzophenone
100 ml chlorobenzene and 14.7 g aluminium trichloride are added in a 250 ml three-neck flask, and then 16.8 g 3,5-dimethyl benzoyl chloride is dropped into the solution at room temperature.
Maintaining the temperature at 70° C., react with stirring for 16 h.
The reaction solution is acidolyzed and washed with water, and then is distilled to remove chlorobenzene, obtaining 21 g residue, the yield is 86%.
The residue is recrystallized with ethanol to obtain a purified white crystal, and the melting point is 72-73° C. ¹H-NMR data (solvent CDCl₃): δ2.371 ppm, s, 6H, δ7.230 ppm, s, 1H, δ7.363 ppm, s, 2H; δ7.438, 7.466 ppm, d, 2H, δ7.729, 7.757 ppm, d, 2H.

References:

US2013/150479,2013,A1 Location in patent:Paragraph 0075; 0076