ChemicalBook CAS DataBase List 4-CHLORO-3-IODOPYRIDINE

4-CHLORO-3-IODOPYRIDINE synthesis

6synthesis methods

Product Name:4-CHLORO-3-IODOPYRIDINE
CAS Number:89167-34-0
Molecular formula:C5H3ClIN
Molecular Weight:239.44

89282-03-1
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$45.00/50mg

89167-34-0
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$10.00/250mg

Yield: 58%

Reaction Conditions:

Stage #1:3-iodo-pyridin-4-ol with trichlorophosphate for 4 h;Heating / reflux;
Stage #2: with ammonia;water at 0 - 20;

Steps:

56.2
Step 2. 4-chloro-3-iodopyridine (47)[00371] A stirred solution under nitrogen of 46 (2.00 g, 9.05 mmol) in POCl₃ (20 ml) was heated to reflux for four hours, then rt. The reaction mixture was poured slowly into ice and the pH was adjusted to 10-1 1 with an aqueous solution of ammonium hydroxide. The aqueous layer was extracted twice with dichloromethane.The combined organic layer was washed with brine, dried over anhydrous Na₂SC^, filtered and concentrated to afford the title compound 47 (1.27 g, 5.30 mmol, 58%) as a brown solid. MS: 239.9 (M+l).

References:

METHYLGENE, INC.;RAEPPEL, Stephane;SAAVEDRA, Oscar;CLARIDGE, Stephen;VAISBURG, Arkadii;GAUDETTE, Frederic;ISAKOVIC, Ljubomir;DEZIEL, Robert WO2008/46216, 2008, A1 Location in patent:Page/Page column 170

626-61-9 Synthesis