(4-Chloro-3-Methoxyphenyl)Methanol synthesis
- Product Name:(4-Chloro-3-Methoxyphenyl)Methanol
- CAS Number:13726-17-5
- Molecular formula:C8H9ClO2
- Molecular Weight:172.61
85740-98-3
154 suppliers
$9.00/250mg
13726-17-5
47 suppliers
$45.00/2.5g
Yield:13726-17-5 99%
Reaction Conditions:
in tetrahydrofuran;
Steps:
C C.
C. Synthesis of (4-chloro-3-methoxyphenyl)methan-1-ol To a solution of 4-chloro-3-methoxybenzoic acid (4.88 g, 26.2 mmol) in THF (50 mL) was added borane-THF complex (52 mL 1M solution in THF, 52 mmol) via addition funnel over 10 min. The reaction mixture was refluxed for 2 hr, cooled, extracted with EtOAc, washed with water, 5% Na2CO3 and brine, dried and concentrated in vacuo to give (4-chloro-3-methoxyphenyl)methan-1-ol (4.5 g, 99%). ES-MS (M+H-H2O)+=155, 157 (Cl).
References:
US2002/77486,2002,A1
13726-16-4
91 suppliers
$8.00/1g
13726-17-5
47 suppliers
$45.00/2.5g
116022-18-5
66 suppliers
$50.00/25g
13726-17-5
47 suppliers
$45.00/2.5g
73909-16-7
44 suppliers
$50.00/1g
13726-17-5
47 suppliers
$45.00/2.5g
615-74-7
107 suppliers
$16.00/5g
13726-17-5
47 suppliers
$45.00/2.5g