4-CHLORO-3-NITROPHENYLACETIC ACID METHYL ESTER synthesis
- Product Name:4-CHLORO-3-NITROPHENYLACETIC ACID METHYL ESTER
- CAS Number:300355-23-1
- Molecular formula:C9H8ClNO4
- Molecular Weight:229.62
98553-93-6
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300355-23-1
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Yield:300355-23-1 89%
Reaction Conditions:
in methanol;
Steps:
65 2-(4-Chloro-3-nitro-phenyl)-3-cyclopentyl-N-pyridin-2-yl-propionamide
EXAMPLE 65 2-(4-Chloro-3-nitro-phenyl)-3-cyclopentyl-N-pyridin-2-yl-propionamide A solution of 4-chloro-3-nitrophenylacetamide (2.00 g, 9.32 mmol) in methanol (40 mL) was treated with Amberlyst 15 ion exchange resin (15.00 g). The resulting reaction mixture was heated under reflux for 64 h. The reaction mixture was allowed to cool to 25° C. and then filtered to remove the Amberlyst 15 ion exchange resin. The filtrate was concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 3/1 hexanes/ethyl acetate) afforded 4-chloro-3-nitro-phenylacetic acid methyl ester (1.91 g, 89%) as a yellow oil: EI-HRMS m/e calcd for C9H8ClNO4 (M+) 229.0142, found 229.0146.
References:
US2001/39344,2001,A1
