4-Chloro-5-(4-nitro-phenyl)-nicotinonitrile synthesis

2synthesis methods

Product Name:4-Chloro-5-(4-nitro-phenyl)-nicotinonitrile
CAS Number:1436405-49-0
Molecular formula:C12H6ClN3O2
Molecular Weight:259.65

104-03-0
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4-Chloro-5-(4-nitro-phenyl)-nicotinonitrile

1436405-49-0
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: thionyl chloride / 1 h / Reflux
2.1: sodium ethanolate / ethanol / 1 h / 50 °C
2.2: 1 h / 0 °C
3.1: water / dimethyl sulfoxide / 1 h / 110 °C
4.1: toluene / 6 h / Reflux
4.2: 2 h / Reflux
5.1: trichlorophosphate; lithium chloride / 3 h / Reflux

References:

Mao, Yongjun;Zhu, Wenxiu;Kong, Xiaoguang;Wang, Zhen;Xie, Hua;Ding, Jian;Terrett, Nicholas Kenneth;Shen, Jingkang [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 11,p. 3090 - 3104]

50434-36-1
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1436405-49-0
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References