4-Chloro-5-Methylthiophen-2-yl hydrogen carbonate synthesis

3synthesis methods

Product Name:4-Chloro-5-Methylthiophen-2-yl hydrogen carbonate
CAS Number:123418-43-9
Molecular formula:C6H5ClO2S
Molecular Weight:176.62

2-Thiophenecarboxylic acid, 4-chloro-5-methyl-, ethyl ester

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4-Chloro-5-Methylthiophen-2-yl hydrogen carbonate

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Yield:-

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran;ethanol;

Steps:

R.144 4-Chloro-5-methyl-2-thiophenecarboxylic Acid

4-Chloro-5-methyl-2-thiophenecarboxylic acid ethyl ester (1.67 g) was dissolved in a mixture of ethanol (10 ml) and tetrahydrofuran (10 ml), and 1N aqueous sodium hydroxide (16 ml) was added. The mixture was stirred at 60° C. for 2 hours and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 4-chloro-5-methyl-2-thiophenecarboxylic acid (0.98 g) as crystals. mp 164°-165° C.

References:

US5840917,1998,A

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References

123418-42-8 Synthesis

1-(4-Chloro-5-methylthiophen-2-yl)ethan-1-one

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References