4-chloro-5-piperazin-1-ylpyridazin-3(2H)-one synthesis
1synthesis methods
- Product Name:4-chloro-5-piperazin-1-ylpyridazin-3(2H)-one
- CAS Number:153276-34-7
- Molecular formula:C8H11ClN4O
- Molecular Weight:214.65
Yield:153276-34-7 81%
Reaction Conditions:
in tetrahydrofuran;lithium hydroxide monohydrate at 80; for 18 h;
Steps:
Compound 534: 4-chloro-5-(piperazin-1-yl)pyridazin-3(2H)-one
To a suspension of 4,5-dichloropyridazin-3-(2H)-one (15.0 g, 1.0 equiv) in a mixture THF (120 mL) I H2O (30 mL) was added piperazine (13.3 g, 1.7 equiv). The reaction mixture was heated at 80°C for 18 hours. The precipitate was filtered, washed with MeOH and dried under vacuum to obtained Compound 534 (15.84 g, 81 %) as a yellow solid.
References:
WO2022/117882,2022,A2 Location in patent:Page/Page column 269