ChemicalBook CAS DataBase List 4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE

4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE synthesis

4synthesis methods

Product Name:4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE
CAS Number:681260-56-0
Molecular formula:C12H6ClFN2S
Molecular Weight:264.71

403-42-9 Synthesis

403-42-9
532 suppliers
$5.00/10g

4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE

681260-56-0
24 suppliers
$75.00/250mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: trichlorophosphate; N,N-dimethyl-formamide / N,N-dimethyl-formamide
2.1: sodium methylate / methanol / 1 h
2.2: 5 h / 60 °C
3.1: 18 h / 180 °C
4.1: trichlorophosphate; N,N-dimethyl-formamide / 6 h / 110 °C

References:

Romagnoli, Romeo;Prencipe, Filippo;Oliva, Paola;Baraldi, Stefania;Baraldi, Pier Giovanni;Schiaffino Ortega, Santiago;Chayah, Mariem;Kimatrai Salvador, Maria;Lopez-Cara, Luisa Carlota;Brancale, Andrea;Ferla, Salvatore;Hamel, Ernest;Ronca, Roberto;Bortolozzi, Roberta;Mariotto, Elena;Mattiuzzo, Elena;Viola, Giampietro [Journal of Medicinal Chemistry,2019,vol. 62,# 3,p. 1274 - 1290]

6-(4-FLUOROPHENYL)-3,4-DIHYDROTHIENO[3,2-D]-PYRIMIDIN-4-ONE

215928-68-0
15 suppliers
$126.00/250mg

681260-56-0
24 suppliers
$75.00/250mg

References

205984-77-6 Synthesis

3-CHLORO-3-(4-FLUOROPHENYL)ACRYLONITRILE

205984-77-6
13 suppliers
inquiry

681260-56-0
24 suppliers
$75.00/250mg

References

METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE

175137-08-3
69 suppliers
$21.21/250mgs:

681260-56-0
24 suppliers
$75.00/250mg

References