ChemicalBook CAS DataBase List 4-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINE

4-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINE synthesis

5synthesis methods

Product Name:4-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINE
CAS Number:175357-98-9
Molecular formula:C7H3ClFN3
Molecular Weight:183.57

171178-44-2
43 suppliers
$200.00/50mg

4-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINE

175357-98-9
72 suppliers
$366.00/100mg

Yield: 100%

Reaction Conditions:

with thionyl chloride in DMF (N,N-dimethyl-formamide) for 7 h;Heating / reflux;

Steps:

A.6.a
DMF (5 drops) was added to a mixture of 6-Fluoro-3H-pyrido [3,4-d] pyrimidin-4-one (0.00605 mol) and thionyl chloride (0.39 mol). The reaction mixture was stirred and refluxed (at 80 C) for 7 hours. The solvent was evaporated, yielding 1.254 g of intermediate (12) (impure quantitative yield; used in next reaction step, without further purification).

References:

JANSSEN PHARMACEUTICA N.V. WO2005/58913, 2005, A1 Location in patent:Page/Page column 38

171178-43-1 Synthesis