4-CHLORO-6-METHYL-2-TRICHLOROMETHYL-QUINOLINE synthesis

Yield:-

Reaction Conditions:

with phosphorus pentachloride in Phosphoroxy chloride;

Steps:

2 2-Trichloromethyl-6-methyl-4-chloroquinoline

EXAMPLE 2 2-Trichloromethyl-6-methyl-4-chloroquinoline The mixture of 1.9 g of 2,6-dimethyl-4-chloro-quinoline and 6.5 g of phosphorus pentachloride is heated in 20 ml of phosphoroxy chloride for 3 hours, then the mixture is admixed with ice water and the separated product is filtered. Yield: 2.81 g; 95.1%.

References:

US4599345,1986,A