4-chloro-6-methylnicotinoyl chloride synthesis
- Product Name:4-chloro-6-methylnicotinoyl chloride
- CAS Number:1005515-30-9
- Molecular formula:C7H5Cl2NO
- Molecular Weight:190.03
33821-58-8
31 suppliers
$46.00/1g
1005515-30-9
3 suppliers
inquiry
Yield:1005515-30-9 94.2%
Reaction Conditions:
with trichlorophosphate at 95; for 16 h;
Steps:
A Step A:
6-Methyl-4-oxo-l,4-dihydropyridine-3 -carboxylic acid (50.0 g, 326.51 mmol) was suspended in phosphoryl trichloride (500.0 g, 3.26 mol) and stirred at 95°C for 16 h. After cooling, the excess phosphorus oxychloride was distilled off in vacuo, and obtained residue was evaporated with toluene (2x250 mL) to give 5-(carboxy)-4-chloro-2-methylpyridin-l- ium chloride (73.3 g, 95.0% purity, 307.46 mmol, 94.2% yield) .
References:
WO2020/221826,2020,A1 Location in patent:Page/Page column 114-115
67367-33-3
205 suppliers
$6.00/5g
1005515-30-9
3 suppliers
inquiry
1060805-95-9
61 suppliers
$8.00/100mg
1005515-30-9
3 suppliers
inquiry