![](/CAS/20180629/GIF/1334602-74-2.gif)
4-chloro-7-morpholinoquinazoline synthesis
- Product Name:4-chloro-7-morpholinoquinazoline
- CAS Number:1334602-74-2
- Molecular formula:C12H12ClN3O
- Molecular Weight:249.7
![3,4-Dihydro-7-(morpholin-4-yl)-4-oxoquinazoline, 4-(3,4-Dihydro-4-oxoquinazolin-7-yl)morpholine](/CAS/GIF/1265848-98-3.gif)
1265848-98-3
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![4-chloro-7-morpholinoquinazoline](/CAS/20180629/GIF/1334602-74-2.gif)
1334602-74-2
31 suppliers
$174.00/1g
Yield:1334602-74-2 93%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;trichlorophosphate at 115; for 2 h;
Steps:
2.1
1.3 ml (7.57 mmol) of N-ethyldiisopropylamine were slowly added dropwise to a suspension of 3.5 g (15.11 mmol) of 7-morpholin-4-yl-3H-quinazolin-4-one in 20 ml of phosphoryl chloride. The reaction mixture was subsequently stirred at 115° C. for 2 h. Conventional work-up gave 3.75 g of 4-chloro-7-morpholin-4-ylquinazoline; HPLC/MS (M+H)+=250 as solid.1H NMR (500 MHz, DMSO) δ 8.84-8.79 (m, 1H), 8.03 (d, J=9.4, 1H), 7.66 (dd, J=9.4, 2.5, 1H), 7.19 (d, J=2.5, 1H), 3.82-3.74 (m, 4H), 3.53-3.45 (m, 4H).
References:
US2013/12489,2013,A1 Location in patent:Paragraph 0189; 0190
![2-Amino-4-bromobenzoic acid](/CAS/GIF/20776-50-5.gif)
20776-50-5
315 suppliers
$10.00/1g
![4-chloro-7-morpholinoquinazoline](/CAS/20180629/GIF/1334602-74-2.gif)
1334602-74-2
31 suppliers
$174.00/1g
![7-BROMO-1H-QUINAZOLIN-4-ONE](/CAS/GIF/194851-16-6.gif)
194851-16-6
172 suppliers
$6.00/1g
![4-chloro-7-morpholinoquinazoline](/CAS/20180629/GIF/1334602-74-2.gif)
1334602-74-2
31 suppliers
$174.00/1g
![7-BROMO-4-CHLOROQUINAZOLINE](/CAS/GIF/573675-55-5.gif)
573675-55-5
157 suppliers
$18.00/250mg
![4-chloro-7-morpholinoquinazoline](/CAS/20180629/GIF/1334602-74-2.gif)
1334602-74-2
31 suppliers
$174.00/1g
![4-(4-methoxybenzyloxy)-7-bromoquinazoline](/CAS/20180703/GIF/1334602-75-3.gif)
1334602-75-3
1 suppliers
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![4-chloro-7-morpholinoquinazoline](/CAS/20180629/GIF/1334602-74-2.gif)
1334602-74-2
31 suppliers
$174.00/1g