4-Chloro-N-isopropylbenzenesulfonaMide, 97% synthesis
- Product Name:4-Chloro-N-isopropylbenzenesulfonaMide, 97%
- CAS Number:28860-19-7
- Molecular formula:C9H12ClNO2S
- Molecular Weight:233.72
Yield:28860-19-7 85%
Reaction Conditions:
with trifluoromethylsulfonic anhydride in 1,4-dioxane at 120; for 48 h;
Steps:
General procedure for the reaction of sulfonamides with alcohols
General procedure: To a mixture of sulfonamide (2 mmol) and alcohol (10 mmol) in 1,4-dioxane (3 mL) was added Tf2O (2 mmol). The mixture was then sealed and stirred at 120 °C until the reaction was completed as judged by TLC. After quenching with satd. aq. NaHCO3, the reaction mixture was extracted three times with EtOAc, dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash chromatography with PE and EtOAc (3: 1) as the eluent to give the pure product.
References:
Yu, Ting Ting;Qi, Lan-Jun;Cui, Dong-Mei;Zhang, Chen;Zhao, Yan [Bulletin of the Chemical Society of Japan,2015,vol. 88,# 4,p. 610 - 612] Location in patent:supporting information
