ChemicalBook CAS DataBase List 4-chloro-N-MethylbenzaMide

4-chloro-N-MethylbenzaMide synthesis

13synthesis methods

Product Name:4-chloro-N-MethylbenzaMide
CAS Number:6873-44-5
Molecular formula:C8H8ClNO
Molecular Weight:169.61

122-01-0
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74-89-5 Synthesis

74-89-5
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6873-44-5
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$45.00/10mg

Yield:6873-44-5 99%

Reaction Conditions:

in tetrahydrofuran at -30 - 20;

Steps:

6 Example 6

At -30° C., about 200 ml of methylamine are condensed into 400 ml of THF. At from -10° C. to 0° C., the reaction solution is then admixed with 75 g of 4-chlorobenzoyl chloride (as a solution in 30 ml of THF). At 20° C., the further progress of the reaction is monitored by thin-layer chromatography. After complete conversion, the compounds contained in the mixture are separated by column chromatography on a silica gel phase using the mobile phase hexane/ethyl acetate (2:1). The main fraction gave, after evaporation of the solvent, 80 g (yield 99% of theory) of N-methyl-4-chloro-benzamide.

References:

US2003/220196,2003,A1 Location in patent:Page/Page column 29