(4-CHLORO-PHENYLAMINO)-PHENYL-ACETIC ACID synthesis

5synthesis methods

Product Name:(4-CHLORO-PHENYLAMINO)-PHENYL-ACETIC ACID
CAS Number:33984-30-4
Molecular formula:C14H12ClNO2
Molecular Weight:261.7

4870-65-9 Synthesis

4870-65-9
187 suppliers
$8.00/1g

106-47-8 Synthesis

106-47-8
465 suppliers
$5.00/5G

(4-CHLORO-PHENYLAMINO)-PHENYL-ACETIC ACID

33984-30-4
15 suppliers
$329.00/1g

Yield:33984-30-4 47%

Reaction Conditions:

in acetonitrile at 100; for 1 h;Microwave irradiation;

Steps:

12

A solution of α-bromophenylacetic acid (1.00 g, 4.65 mmol) in acetonitrile (20 mL), is added with 4-chloro-phenylamine (1.18 g, 9.30 mmol) and the mixture reacted in a closed vessel under MW irradiation at 100⁰C for 1 h (UPLC-MS monitoring: complete conversion). Solvent is evaporated and residue is partitioned between EtOAc and IN HCl. The organic phase is dried over Na₂SO₄, filtered and evaporated to dryness to get intermediate 176 as a yellow solid (0.57 g; 47% yield).

References:

WO2010/72338,2010,A1 Location in patent:Page/Page column 69-70