(4-Chloro-pyriMidin-2-yl)-diMethyl-aMine synthesis

6synthesis methods

Product Name:(4-Chloro-pyriMidin-2-yl)-diMethyl-aMine
CAS Number:23631-02-9
Molecular formula:C6H8ClN3
Molecular Weight:157.6

3993-78-0 Synthesis

3993-78-0
310 suppliers
$8.00/1g

74-88-4
344 suppliers
$15.00/10g

(4-Chloro-pyriMidin-2-yl)-diMethyl-aMine

23631-02-9
33 suppliers
$45.00/10mg

Yield:23631-02-9 89%

Reaction Conditions:

Stage #1: 2-amino-4-chloropyrimidinewith sodium hydride in tetrahydrofuran at 0 - 20; for 0.0833333 h;
Stage #2: methyl iodide at 20; for 16 h;

References:

Henderson, Scott H.;Sorrell, Fiona;Bennett, James;Fedorov, Oleg;Hanley, Marcus T.;Godoi, Paulo H.;Ruela De Sousa, Roberta;Robinson, Sean;Ashall-Kelly, Alexander;Hopkins Navratilova, Iva;Walter, Daryl S.;Elkins, Jonathan M.;Ward, Simon E. [Journal of Medicinal Chemistry,2021,vol. 64,# 15,p. 11709 - 11728] Location in patent:supporting information

3934-20-1 Synthesis