4'-chloroflavone synthesis
- Product Name:4'-chloroflavone
- CAS Number:10420-75-4
- Molecular formula:C15H9ClO2
- Molecular Weight:256.68
3033-96-3
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Yield:10420-75-4 97%
Reaction Conditions:
with Iodine monochloride;dimethyl sulfoxide at 50; for 0.5 h;Sonication;Green chemistry;
Steps:
General procedure for the synthesis of flavones
General procedure: For a typical synthesis, 2′-hydroxychalcones (0.5mmol) was dissolved in Wijs’ reagent (5mL). The acetic acid was removed in vacuo. Then, the resulting solid and DMSO (5mL) were charged in a 10mL glass reactor. The reaction mixture was heated in an oil bath at 50±2°C. The ultrasound probe was immersed directly in the reactor. The ultrasonic generator (Bioblock Scientific 750W) emits the sound vibration into the reaction mixture. Sonification was achieved at low frequencies of 20kHz (amplitude of 30%). The reaction time was fixed at 30min. When the reaction time was over, the mixture was allowed to cool, poured into 10mL water and extracted with chloroform (3×20mL). The organic layer was washed with sodium thiosulphate (3×10mL) until neutrality and dried with MgSO4 anhydrous. After filtration, the solvent was removed under reduced pressure to furnish the crude product. The yields of the reactions were calculated from the mass of the isolated pure product.
References:
Lahyani, Achraf;Trabelsi, Mahmoud [Ultrasonics Sonochemistry,2016,vol. 31,p. 626 - 630]
65599-34-0
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$47.00/1g
10420-75-4
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