4-ChloroMethyl-2-trifluoroMethyl-pyridine synthesis

2synthesis methods

Product Name:4-ChloroMethyl-2-trifluoroMethyl-pyridine
CAS Number:1027545-48-7
Molecular formula:C7H5ClF3N
Molecular Weight:195.57

(2-Trifluoromethyl-pyridin-4-yl)-methanol

131747-61-0
97 suppliers
$100.00/100mg

4-ChloroMethyl-2-trifluoroMethyl-pyridine

1027545-48-7
34 suppliers
inquiry

Yield:1027545-48-7 60%

Reaction Conditions:

with thionyl chloride in dichloromethane at 0 - 60; for 1 h;

Steps:

2 Step 2: 4-(chloromethyl)-2-(trifluoromethyl)pyridine

To a mixture of (2- (trifluoromethyl) pyridin-4-yl) methanol A-2 (400 mg, 2 mmol) in dichloromethane (5mL) was added SOCl₂(2mL) slowly at 0 . The reaction mixture wa stirred at 60 for 1 h. The reaction mixture was then quenched with 1 mL saturated aqueous NH₄Cl and extracted with ethyl acetate (5mL × 3) . The combined organic extracts were concentrated in vacuo, the residue was purified on silica gel (EtOAc: petroleum ether 1: 5) to give the product as a solid (300 mg, 60 ) MS (ESI) calc’dfor (C₇H₅ClF₃N) [M+H]⁺: 195.0 found: 195

References:

WO2016/29454,2016,A1 Location in patent:Page/Page column 59; 60

131747-41-6 Synthesis

131747-41-6
219 suppliers
$10.00/1g

1027545-48-7
34 suppliers
inquiry

References