4-(chloromethyl)-7,8-dihydroxy-2-benzopyrone synthesis
- Product Name:4-(chloromethyl)-7,8-dihydroxy-2-benzopyrone
- CAS Number:19040-71-2
- Molecular formula:C10H7ClO4
- Molecular Weight:226.61
Yield: 69%
Reaction Conditions:
with perchloric acidPechmann Condensation;
Steps:
General procedure for the synthesis of 4-substituted daphnetin derivatives (2-6)
General procedure: Perchloric acid (5.0 mL)was added drop-wise at room temperature to a mixture of 1,2,3-phenenyl triacetate (5.0 mmol) andthe correctly substituted b-ketoester (10.0 mmol) and stirred for 6-8 h. After TLC analysis indicatedthat the reaction was complete, the reaction mixture was slowly poured into a mixture of ice water(100 mL) with stirring. The resultant suspension was filtered, and the collected solid was washedwith water and dried; the crude compound was recrystallized from methanol to produce the desiredcompound [30].
References:
Xia, Yangliu;Chen, Chen;Liu, Yong;Ge, Guangbo;Dou, Tongyi;Wang, Ping [Molecules,2018,vol. 23,# 10,art. no. Y]
