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(4-CHLOROMETHYL-PHENOXY)-ACETIC ACID ETHYL ESTER synthesis

3synthesis methods
Acetic acid, [4-(hydroxymethyl)phenoxy]-, ethyl ester

103258-64-6
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(4-CHLOROMETHYL-PHENOXY)-ACETIC ACID ETHYL ESTER

80494-75-3
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Yield:80494-75-3 100%

Reaction Conditions:

with thionyl chloride in dichloromethane;N,N-dimethyl-formamide at 0; for 0.75 h;Inert atmosphere;

References:

Toma?i?, Tihomir;Zidar, Nace;?ink, Roman;Kova?, Andreja;Blanot, Didier;Contreras-Martel, Carlos;Dessen, Andréa;Müller-Premru, Manica;Zega, Anamarija;Gobec, Stanislav;Kikelj, Danijel;Peterlin Ma?i?, Lucija [Journal of Medicinal Chemistry,2011,vol. 54,# 13,p. 4600 - 4610] Location in patent:supporting information; experimental part