4-CHLORONAPHTHALIMIDE synthesis

Yield:39061-32-0 91.12%

Reaction Conditions:

with ammonium hydroxide at 65; for 5 h;

Steps:

1 Example 4:

4-chloro-1,8-naphthalic anhydride (349mg, 1.5mmol)It was heated to reflux with ammonia water (40ml) at 65°C for 5 hours,After the reaction is over,The crude product containing the compound of formula (IX) is obtained by suction filtration under reduced pressure.The crude product is further separated by chromatographic column,Dichloromethane is the eluent,318 mg of pure compound of formula (IX) were obtained as pale yellow,The yield was 91.12%.

References:

CN114249691,2022,A Location in patent:Paragraph 0078-0084