4-chlorophenyl salicylate synthesis

9synthesis methods

Product Name:4-chlorophenyl salicylate
CAS Number:2944-58-3
Molecular formula:C13H9ClO3
Molecular Weight:248.66

444-30-4 Synthesis

444-30-4
263 suppliers
$6.00/5g

106-48-9
468 suppliers
$10.00/5G

2944-58-3
14 suppliers
$106.00/250mg

Yield:2944-58-3 91%

Reaction Conditions:

with water;potassium carbonate in toluene at 120; for 12 h;

Steps:

2. General procedure for the reaction

General procedure: 1 (0.2 mmol, 1.0 equiv.), 2 (0.24mmol, 1.2 equiv.), K₂CO₃ (0.4 mmol, 2.0 equiv.), and toluene/H₂O (V/V = 95:5, 2.0 mL) were added to a test tube at 120 °C in an oil bath under air overnight. After the disappearance of the substrate as indicated by TLC, the mixture was extracted by DCM (3 × 5 mL). The organic layers were combined and dried by Na₂SO₄. The solvent was removed under vacuum and the residue was purified by silica gel chromatography, using a mixture of petroleum ether/ethyl acetate to give the desired product 3.

References:

Lin, Chuankai;Liu, Jin-Biao;Wang, Ruixiang;Xie, Huilin [Tetrahedron Letters,2022,vol. 89,art. no. 153592] Location in patent:supporting information