4-CYANO-2,6-DIFLUOROBENZOIC ACID synthesis
- Product Name:4-CYANO-2,6-DIFLUOROBENZOIC ACID
- CAS Number:181073-82-5
- Molecular formula:C8H3F2NO2
- Molecular Weight:183.11
467442-15-5
102 suppliers
$18.00/50mg
181073-82-5
69 suppliers
inquiry
Yield:181073-82-5 91.32%
Reaction Conditions:
with sodium chlorite;potassium dihydrogenphosphate;aminosulfonic acid in water;dimethyl sulfoxide at 20; for 1 h;
Steps:
b
Step b: Synthesis of 4-cyano-2,6-difluoro benzoic acidTo a solution of 3,5-difluoro-4-formylbenzonitrile (0.2g, 1 .1 mmol) in dimethylsulfoxide (10 mL), were added a aqueous solution of potassium dihydrogen phosphate (0.41 g, 2.9 mmol in 0.4 mL of water), sodium chlorite (0.216 g, 2.3 mmol in 4 mL of water) in one lot at an ambient temperature. The resulting reaction mixture was stirred for about 1 hour. The reaction mass was diluted with water (100 mL). The aquoeus phase was extracted with ethyl acetate (3x100 mL).The combined organic layer dried over anhydrous sodium sulfate, filtered and concentrated to afford 4-cyano-2,6-difluorobenzoic acid (200 mg, 91 .32 %) .1 H NMR (400 MHz, DMSO-d6): δ 7.95 (d, J=7.53 Hz, 2H).
References:
DAIICHI SANKYO COMPANY, LIMITED;VERMA, Ashwani, Kumar;NAGASWAMY, Kumaragurubaran;SHARMA, Lalima;GHOSH, Soma;KALE, Balkrishna, Ramchandra;MONDAL, Aniruddha;SRIVASTAVA, Punit, Kumar;DASTIDAR, Sunanda, Ghosh;MIYAUCHI, Rie;MURATA, Takeshi;ISHIZAKI, Masayuki;NAGAMOCHI, Masatoshi;IIMURA, Shin;MOMIN, Rijwan, Jaffer;WAGH, Pradip, Balu;PANSARE, Sonali, Nanasaheb;MARKAD, Pramod, Raosaheb;KHAIRNAR, Yogesh, Balasaheb WO2012/160464, 2012, A1 Location in patent:Page/Page column 69
124-38-9
122 suppliers
$175.00/23402
64248-63-1
296 suppliers
$6.00/5g
181073-82-5
69 suppliers
inquiry
64248-63-1
296 suppliers
$6.00/5g
181073-82-5
69 suppliers
inquiry