ChemicalBook CAS DataBase List 4-Cyano-2-Methyl-1H-indole

4-Cyano-2-Methyl-1H-indole synthesis

7synthesis methods

Product Name:4-Cyano-2-Methyl-1H-indole
CAS Number:1360883-22-2
Molecular formula:C10H8N2
Molecular Weight:156.18

16136-52-0
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C
1.2: 0.5 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -40 °C
2.2: 3 h / -40 - 20 °C
3.1: sodium hydroxide / lithium hydroxide monohydrate; ethanol / 3 h / 40 °C

References:

Zhou, Han-Jie;Wang, Jinhai;Yao, Bing;Wong, Steve;Djakovic, Stevan;Kumar, Brajesh;Rice, Julie;Valle, Eduardo;Soriano, Ferdie;Menon, Mary-Kamala;Madriaga, Antonett;Kiss Von Soly, Szerenke;Kumar, Abhinav;Parlati, Francesco;Yakes, F. Michael;Shawver, Laura;Le Moigne, Ronan;Anderson, Daniel J.;Rolfe, Mark;Wustrow, David [Journal of Medicinal Chemistry,2015,vol. 58,# 24,p. 9480 - 9497]

6127-18-0 Synthesis