4-CYANOCINNAMALDEHYDE synthesis

13synthesis methods

Product Name:4-CYANOCINNAMALDEHYDE
CAS Number:41917-85-5
Molecular formula:C10H7NO
Molecular Weight:157.17

Benzonitrile, 4-[(1E)-3-hydroxy-1-propen-1-yl]-

99154-06-0
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41917-85-5
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Yield:41917-85-5 193 mg

Reaction Conditions:

with manganese(IV) oxide in dichloromethane at 20; for 5 h;

Steps:

13.4 Preparation 13: (E)-4-(3 -oxoprop- 1-en-i -yl)benzonitrile

Step 4: To a solution of alcohol (238 mg, 1.5 mmol) in dry DCM (10 mL), Mn02(1.95 g, 22.5 mmol) was added, and the reaction was stirred at room temperature for 5 h. The solid was removed by filtration (washing with DCM), and the filtrate was evaporated todryness to give the title compound (193 mg, purity: 92% by UV a/a, recovery 82%).

References:

WO2016/185423,2016,A1 Location in patent:Page/Page column 83