4-Cyanophenyl-4'-Methylbenzoate synthesis
- Product Name:4-Cyanophenyl-4'-Methylbenzoate
- CAS Number:32792-42-0
- Molecular formula:C15H11NO2
- Molecular Weight:237.25
Yield:32792-42-0 66 %
Reaction Conditions:
with (1,2-dimethoxyethane)dichloronickel(II);sodium carbonate;4,4'-di-tert-butyl-2,2'-bipyridine in 1,2-dichloro-ethane at 30;Inert atmosphere;Irradiation;
Steps:
4 Embodiment 4: p-tolualdehyde and p-cyanophenol reaction
Under N2 atmosphere, p-tolualdehyde (0.5 mmol), p-cyanophenol (0.2 mmol), NiCl2 glyme (0.02 mmol, 10 mol%), dtbbpy (0.024 mmol, 12 mol%), Na2CO3 (0.2 mmol) and DCE (1 mL) were placed in a dry reaction tube with a magnetic stir bar, irradiated with 2 × 3 W 365 nm LEDs at 30 °C and stirred routinely for 24 h. After the reaction, add 3 mL of water, then extract the mixture 3 times with 3 × 3 mL of ethyl acetate, combine the organic phases, then dry with anhydrous sodium sulfate, filter, and the filtrate is evaporated under reduced pressure, and passed through a silica gel chromatography column Purified by chromatography to obtain the target product (yield 84%).
References:
CN115466199,2022,A Location in patent:Paragraph 0026-0027
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