4-CYCLOHEXYLAMINO-3-NITRO-BENZOIC ACID synthesis
- Product Name:4-CYCLOHEXYLAMINO-3-NITRO-BENZOIC ACID
- CAS Number:333340-82-2
- Molecular formula:C13H16N2O4
- Molecular Weight:264.28
Yield:333340-82-2 87%
Reaction Conditions:
with D-myo-inositol;copper;caesium carbonate in water at 100;
Steps:
The reaction of4-chloro-3-nitrobenzoic acid (0.202 g, 1.0 mmol), cyclohexanamine (0.150 g, 1.5mmol), copper powder (0.0064 g, 0.1 mmol), MI (0.036 g, 0.2 mmol), Cs2CO3 (0.98 g,3.0 mmol), TBAHS (0.068 g, 0.2 mmol) produced 0.230 g (87%) of4-(cyclohexylamino)-3-nitrobenzoic acid as a white solid.
References:
Zhou, Qifan;Du, Fangyu;Chen, Yuanguang;Fu, Yang;Chen, Guoliang [Tetrahedron Letters,2019,vol. 60,# 29,p. 1938 - 1941] Location in patent:supporting information
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