![](/CAS/GIF/1131-60-8.gif)
4-Cyclohexylphenol synthesis
- Product Name:4-Cyclohexylphenol
- CAS Number:1131-60-8
- Molecular formula:C12H16O
- Molecular Weight:176.25
The hydroalkylation of phenol in the presence of palladium catalyst and fused salt (NaCl-AlCl3) under hydrogen pressure was carried out. By using 1% Pd-Al2O3 (1 g) and the fused salt (1 : 1 mol ratio, 6 g), 4-cyclohexylphenol was obtained selectively from 1 (30 g) in a yield of 31.9% at 120°C for 4.5 h.
![4-Bromophenol](/CAS/GIF/106-41-2.gif)
106-41-2
482 suppliers
$13.00/5g
![4-Cyclohexylphenol](/CAS/GIF/1131-60-8.gif)
1131-60-8
178 suppliers
$9.00/5g
Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: methyllithium / tetrahydrofuran; diethyl ether / 1 h / -30 °C
1.2: 0.25 h / -30 °C
1.3: 1 h / -30 °C
2.1: Martins sulfurane / tetrahydrofuran; diethyl ether; pentane / -30 °C
References:
Wilson, Claire M.;Ganesh, Venkataraman;Noble, Adam;Aggarwal, Varinder K. [Angewandte Chemie - International Edition,2017,vol. 56,# 51,p. 16318 - 16322][Angew. Chem.,2017,vol. 129,# 51,p. 16536 - 16540,5]
![Cyclohexene](/CAS/GIF/110-83-8.gif)
110-83-8
292 suppliers
$11.00/25g
![Phenol](/CAS/20180808/GIF/108-95-2.gif)
108-95-2
723 suppliers
$14.00/25g
![2-CYCLOHEXYLPHENOL](/CAS/GIF/119-42-6.gif)
119-42-6
81 suppliers
$27.00/5g
![DICYCLOHEXYLPHENOL](/CAS/GIF/35406-29-2.gif)
35406-29-2
0 suppliers
inquiry
![4-Cyclohexylphenol](/CAS/GIF/1131-60-8.gif)
1131-60-8
178 suppliers
$9.00/5g
![4-Phenylphenol](/CAS/GIF/92-69-3.gif)
92-69-3
414 suppliers
$6.00/25g
![4-Cyclohexylphenol](/CAS/GIF/1131-60-8.gif)
1131-60-8
178 suppliers
$9.00/5g
![Cyclohexanol](/CAS/GIF/108-93-0.gif)
108-93-0
417 suppliers
$11.00/25g
![Phenol](/CAS/20180808/GIF/108-95-2.gif)
108-95-2
723 suppliers
$14.00/25g
![2-CYCLOHEXYLPHENOL](/CAS/GIF/119-42-6.gif)
119-42-6
81 suppliers
$27.00/5g
![DICYCLOHEXYLPHENOL](/CAS/GIF/35406-29-2.gif)
35406-29-2
0 suppliers
inquiry
![4-Cyclohexylphenol](/CAS/GIF/1131-60-8.gif)
1131-60-8
178 suppliers
$9.00/5g
![Cyclohexanol](/CAS/GIF/108-93-0.gif)
108-93-0
417 suppliers
$11.00/25g
![Phenol](/CAS/20180808/GIF/108-95-2.gif)
108-95-2
723 suppliers
$14.00/25g
![2-CYCLOHEXYLPHENOL](/CAS/GIF/119-42-6.gif)
119-42-6
81 suppliers
$27.00/5g
![4-Cyclohexylphenol](/CAS/GIF/1131-60-8.gif)
1131-60-8
178 suppliers
$9.00/5g