4-Cyclopropyl-1(3)H-iMidazole synthesis
- Product Name:4-Cyclopropyl-1(3)H-iMidazole
- CAS Number:89830-98-8
- Molecular formula:C6H8N2
- Molecular Weight:108.14
69267-75-0
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3473-63-0
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89830-98-8
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$45.00/10mg
Yield: 93.7%
Reaction Conditions:
in 1,2-dimethoxyethane at 110; for 15 h;Solvent;Temperature;
Steps:
1.1.1; 3.3.1; 6.6.1 Synthesis of 3.1, 4-cyclopropyl-1H-imidazole
The compound 2-bromo-1-cyclopropylethanone (12.0 g, 74.1 mmol) and formamidine acetate (23.1 g, 222.3 mmol) were dissolved in 100 mL of ethylene glycol and reacted at 110 ° C for 15 hours. After the reaction was completed, 500 mL of water was added, and the mixture was washed three times with dichloromethane (500 mL×3), then the aqueous phase was adjusted to pH 8 with a 1 M aqueous NaOH solution, and the aqueous phase was extracted twice with dichloromethane (500 mL×2), organic phase was dried and concentrated to give the desired product 7.5g, yield 93.7%.
References:
Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.;Wang Tingzhong CN110294746, 2019, A Location in patent:Paragraph 0121-0124; 0176-0179; 0217-0220
765-43-5
414 suppliers
$10.00/1g
89830-98-8
60 suppliers
$45.00/10mg