ChemicalBook CAS DataBase List 4-(dibenzofuran-4-group) phenylboric acid

4-(dibenzofuran-4-group) phenylboric acid synthesis

7synthesis methods

Product Name:4-(dibenzofuran-4-group) phenylboric acid
CAS Number:796071-96-0
Molecular formula:C18H13BO3
Molecular Weight:288.11

955959-84-9 Synthesis

955959-84-9
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5419-55-6
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7732-18-5
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4-(dibenzofuran-4-group) phenylboric acid

796071-96-0
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Yield:796071-96-0 96%

Reaction Conditions:

Stage #1: 4-(4-bromophenyl)dibenzofuranwith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;
Stage #2: Triisopropyl borate in tetrahydrofuran;hexane; for 12 h;
Stage #3: water in tetrahydrofuran;hexane;

Steps:

6

Preparation of compound C-6-2 [135] After dissolving compound C-6-1 (17 g, 52.6 mmol) in THF (400 ml), and adding 2.5 M n-BuLi in hexane (31.5 ml, 78.9 mmol) to the reaction mixture in -78°C, the reaction mixture was stirred for 1 hour. The reaction mixture was stirred for 12 hours with adding B(Oi-Pr) (24.1 ml, 105.2 mmol) slowly to the reaction mixture. After terminating the reaction, purified water 20 mL was dropped slowly to the reaction mixture. The reaction mixture was extracted with EA/NH₄Cl aqueous solution. The obtained organic layer was concentrated, was triturated with MC/hexane, and then was filtered to obtain compound C-6-2 (14.5 g, 96 %).

References:

WO2012/141499,2012,A1 Location in patent:Page/Page column 19

955959-84-9 Synthesis

955959-84-9
130 suppliers
$7.00/100mg