4-DIBROMOMETHYL-BENZOIC ACID METHYL ESTER synthesis

5synthesis methods

Product Name:4-DIBROMOMETHYL-BENZOIC ACID METHYL ESTER
CAS Number:131852-50-1
Molecular formula:C9H8Br2O2
Molecular Weight:307.97

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149-73-5 Synthesis

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4-DIBROMOMETHYL-BENZOIC ACID METHYL ESTER

131852-50-1
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Yield:131852-50-1 98.8%

Reaction Conditions:

with zinc(II) chloride in chloroform at 50; for 0.5 h;

Steps:

Reaction of 4-(dibromomethyl)benzoyl bromide(18) with trimethyl orthoformate (12a). a. Reactantratio 1 : 1.

Ortho ester 12a, 0.30 g (0.00280 mol), andzinc chloride, 0.04 g (0.00028 mol), were added to asolution of 1.00 g (0.00280 mol) of compound 18 in5 mL of chloroform, and the mixture was heated for30 min at 50°C. Removal of the solvent and volatilecomponents under reduced pressure left 0.85 g(98.8%) of methyl 4-(dibromomethyl)benzoate (17) ascolorless crystals with mp 70-71°C (from pentane).

References:

Gazizov;Ivanova, S. Yu.;Khairullin;Kirillina, Yu. S.;Gazizova [Russian Journal of General Chemistry,2018,vol. 88,# 11,p. 2243 - 2250][Zh. Obshch. Khim.,2018,vol. 88,# 11,p. 1761 - 1769,9]

99-75-2 Synthesis