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1014-03-5

4-(diethoxyMethyl)pyriMidin-2-aMine synthesis

2synthesis methods
-

Yield:1014-03-5 95%

Reaction Conditions:

Stage #1: guanidine hydrochloridewith sodium hydride in ethanol at 20; for 0.25 h;Inert atmosphere;
Stage #2: 1,1-diethoxybut-3-yn-2-one in ethanol at 20; for 0.75 h;Inert atmosphere;

References:

Sengee, Myagmarsuren;Sydnes, Leiv K. [Synthesis,2011,# 23,art. no. Z78711SS,p. 3899 - 3907] Location in patent:experimental part