4'-DIMETHYLAMINO-2-PHENYLACETOPHENONE synthesis

Yield:97606-39-8 88 %Chromat.

Reaction Conditions:

with potassium tert-butylate in acetonitrile at 81; for 2 h;Inert atmosphere;Schlenk technique;

Steps:

2.7. Catalysis and recycling

General procedure: The catalytic experiments were carried out using potassium tertbutoxide(1.5 mmol) as a base, functionalized silica materials (approx.Pd content 1.0 mol%) as catalyst, and ketone (1.0 mmol), and aryl halide(1.2 mmol) as reagents in acetonitrile (10 mL) at reflux temperature.After cooling the reaction mixture, the reaction vessel was centrifugedto settle the silica and the catalyst was separated from theliquid product by decanting the supernatant carefully and then filtration.The filtrate was analyzed by gas chromatography to determine theyield of the product. The recovered catalyst was washed twice withCH2Cl2 and dried in vacuo. It was then used for the next run.

References:

Kai, Wang;Qian, Hua;Liu, Dabin;Ye, Zhiwen [Molecular catalysis,2019,vol. 462,p. 85 - 91]