ChemicalBook CAS DataBase List 4-(DIMETHYLAMINO)BENZONITRILE

4-(DIMETHYLAMINO)BENZONITRILE synthesis

10synthesis methods

Product Name:4-(DIMETHYLAMINO)BENZONITRILE
CAS Number:1197-19-9
Molecular formula:C9H10N2
Molecular Weight:146.19

100-10-7 Synthesis

100-10-7
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1197-19-9
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$31.00/5g

Yield:1197-19-9 99%

Reaction Conditions:

with ammonia;iodine in water;N,N-dimethyl-formamide at 20; for 0.666667 h;

Steps:

5 Example 5
Order of addition: In 100 mL round-bottom flask, 0.151 g of p-dimethylaminobenzaldehyde is dissolved in DMF, and addition of I2 to the reaction system, the reaction system was reddish brown. After addition of aqueous ammonia followed by 0.8 mL, room temperature, while stirring the reaction 10 min, TLC plate point to verify the reaction completion. Aqueous ammonia was added 0.8 mL, half an hour the reaction, the reaction system was orange-red, continuously adding ammonia to the reaction system until the completion of the reaction by TLC, was added Na2S203 (sodium thiosulfate) removal of excess I2 (iodine) was added to a round bottom flask , pure water was added, extracted with chloroform, and then the product Na2S04 (anhydrous sodium sulfate) as desiccant, the last rotary evaporation with a rotary evaporator instruments, to give the product, yield 99%.

References:

Yancheng Normal College;Wang Jin;Hu Xiao;Wang Wenling;Geng Rongqing;Qiu Qiong;Shao Jin;Jin Wenbin;Yan Yiyu;Zhai Yulin;Zhu Xiaoming CN107382771, 2017, A Location in patent:Paragraph 0021

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