4-Ethoxy-2,6-difluorobenzamide synthesis
- Product Name:4-Ethoxy-2,6-difluorobenzamide
- CAS Number:916483-57-3
- Molecular formula:C9H9F2NO2
- Molecular Weight:201.17
916483-56-2
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$61.00/1g
916483-57-3
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$95.00/250mg
Yield:916483-57-3 93%
Reaction Conditions:
Stage #1: 4-ethoxy-2,6-difluorobenzoic acidwith oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 18 - 25;
Stage #2: with ammonia in tetrahydrofuran;water;
Steps:
1.c
c) Oxalyl chloride (3.17 ml, 36.4 mmol) was added dropwise to a stirred suspension of 4-ethoxy-2,6-difluorobenzoic acid (3.5 g, 17.3 mmol) and dimethylformamide (5 drops) in dichloromethane (50 ml). The resulting solution was stirred at room temperature for 4 hours and was then evaporated. The residue was dissolved in tetrahydrofuran and then added dropwise to a vigorously stirring 35% aqueous ammonia solution (60 ml). The mixture was filtered and the residue was washed with ice-cold water and then dried under vacuum to leave 4-ethoxy-2,6-difluorobenzamide as a colourless solid (3.23 g, 93% yield):1H-NMR (DMSO d6): 7.91 (br. s, 1H), 7.65 (br. s, 1H), 6.78-6.71 (m, 2H), 4.08 (q, 2H), 1.32 (t, 3H).MS (+ve EI): 201 (M+)
References:
US2010/168143,2010,A1 Location in patent:Page/Page column 12
1373920-79-6
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$32.20/250mg
916483-57-3
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$95.00/250mg
144891-25-8
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$58.00/500mg
916483-57-3
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$95.00/250mg
2713-34-0
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$5.00/1g
916483-57-3
14 suppliers
$95.00/250mg