![](/CAS/GIF/937-30-4.gif)
4-Ethylacetophenone synthesis
- Product Name:4-Ethylacetophenone
- CAS Number:937-30-4
- Molecular formula:C10H12O
- Molecular Weight:148.2
![Ethylbenzene](/CAS/GIF/100-41-4.gif)
100-41-4
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![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
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![4-Ethylacetophenone](/CAS/GIF/937-30-4.gif)
937-30-4
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$25.00/25g
Yield:937-30-4 86%
Reaction Conditions:
with aluminum (III) chloride in dichloromethane at -70 - -50; for 5 h;
Steps:
2.1
Example 2; Synthesis of 4-bromo-7-ethyl-6-methoxvcinnoline; [00187] Step 1. Aluminum (III) chloride (27 g, 202.49 mmol) was added to a chilled solution of 1-ethylbenzene (10.6 g, 99.85 mmol) in methylene chloride (100 mL) at -70 0C. A solution of acetic anhydride (10.2 g, 99.91 mmol) in methylene chloride (20 mL) was added dropwise over 3 hr, while maintaining the temperature at -70 0C. The resulting solution was maintained for 2 hr between -70 and -500C, then added to a mixture of ice and hydrochloric acid (100 mL). The product was extracted with methylene chloride and the organic, dried, filtered, and concentrated to afford 15 g (86 % yield) of l-(4- ethylphenyl)ethanone as a colorless liquid.
References:
AMGEN INC.;MEMORY PHARMACEUTICALS CORPORATION WO2007/103260, 2007, A1 Location in patent:Page/Page column 59
![4-Ethylphenylacetylene](/CAS/GIF/40307-11-7.gif)
40307-11-7
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![4-Ethylacetophenone](/CAS/GIF/937-30-4.gif)
937-30-4
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![4-ACETYLPHENYLACETYLENE](/CAS/GIF/42472-69-5.gif)
42472-69-5
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![1-(4-VINYL-PHENYL)-ETHANONE](/CAS/GIF/10537-63-0.gif)
10537-63-0
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![4-Ethylacetophenone](/CAS/GIF/937-30-4.gif)
937-30-4
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![1,4-DIETHYLBENZENE](/CAS/GIF/105-05-5.gif)
105-05-5
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![4-Ethylacetophenone](/CAS/GIF/937-30-4.gif)
937-30-4
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105-05-5
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![4-Ethylacetophenone](/CAS/GIF/937-30-4.gif)
937-30-4
202 suppliers
$25.00/25g
![1,4-Diacetylbenzene](/CAS/GIF/1009-61-6.gif)
1009-61-6
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