4-[(ETHYLSULFONYL)AMINO]BENZOIC ACID synthesis

5synthesis methods

Product Name:4-[(ETHYLSULFONYL)AMINO]BENZOIC ACID
CAS Number:116855-56-2
Molecular formula:C9H11NO4S
Molecular Weight:229.25

544451-83-4 Synthesis

544451-83-4
22 suppliers
$55.00/250mg

116855-56-2
13 suppliers
$60.00/50mg

Yield:116855-56-2 1.3 g

Reaction Conditions:

with water;sodium hydroxide in methanol at 0 - 20; for 6 h;

Steps:

4.2 Step 2: Synthesis of 4-(ethylsulfonamido)benzoic acid

Methyl 4-(ethylsulfonamido)benzoate (2.3 g, wet) and MeOH (15 ml) were added to a 100 ml three-neck round bottom flask. The reaction mixture was stirred with ice bath. NaOH aqueous (15 ml) was added dropwise to the reaction mixture at 0-5 °C. Then the reaction wasallowed to warm to room temperature and kept for 6 hours. The methanol was removed under vacuum at 45 °C and the remaining mixture was treated with HC1 (conc.) to adjust its pH to 2). Some solids appeared. The solids were collected by filtration and the collected solids were washed with water to give the product wet (1.3 g), kept at room temperature overnight.

References:

WO2019/29629,2019,A1 Location in patent:Paragraph 00102; 00105; 00106

94-09-7 Synthesis