![](/CAS/GIF/10602-00-3.gif)
4-ETHYNYL-BENZOIC ACID synthesis
- Product Name:4-ETHYNYL-BENZOIC ACID
- CAS Number:10602-00-3
- Molecular formula:C9H6O2
- Molecular Weight:146.14
![4-ETHYNYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/3034-86-4.gif)
3034-86-4
183 suppliers
$6.00/100mg
![4-ETHYNYL-BENZOIC ACID](/CAS/GIF/10602-00-3.gif)
10602-00-3
200 suppliers
$10.00/250mg
Yield:10602-00-3 77%
Reaction Conditions:
with lithium hydroxide in methanol;water for 2 h;
Steps:
21 Synthesis of Compound B 11
To a solution of 2 ( 0.5 g, 3.13 mmol) in MeOH (10 ml) was added LiOH (0.312 g. 12.52mmol) in water (10 ml). The mixture was stirred for 2 h then quenched by HCI solution (2N) extracted with EtOAc (30 ml x 3). The combined organic was dried over anhydrous Na2SO4 concentrated to give the desired intermediate 3 (0.35 g, 77%) as yellow solid.
References:
HANGZHOU ZYLOX PHARMA CO., LTD.;WANG, Bing;ZHAO, Jonathon Zhong WO2014/82286, 2014, A1 Location in patent:Paragraph 67
![methyl 4-(2-(trimethylsilyl)ethynyl)benzoate](/CAS/GIF/75867-41-3.gif)
75867-41-3
28 suppliers
$414.00/0.25G
![4-ETHYNYL-BENZOIC ACID](/CAS/GIF/10602-00-3.gif)
10602-00-3
200 suppliers
$10.00/250mg
![ethyl 4-(2-(trimethylsilyl)ethynyl)benzoate](/CAS/20180703/GIF/150969-54-3.gif)
150969-54-3
5 suppliers
inquiry
![4-ETHYNYL-BENZOIC ACID](/CAS/GIF/10602-00-3.gif)
10602-00-3
200 suppliers
$10.00/250mg
![4-(3-HYDROXY-3-METHYLBUT-1-YNYL)BENZOIC ACID METHYL ESTER](/CAS/GIF/33577-98-9.gif)
33577-98-9
18 suppliers
$496.12/5MG
![4-ETHYNYL-BENZOIC ACID](/CAS/GIF/10602-00-3.gif)
10602-00-3
200 suppliers
$10.00/250mg
![4-((Trimethylsilyl)ethynyl)benzoic acid](/CAS/GIF/16116-80-6.gif)
16116-80-6
35 suppliers
$80.00/1g
![4-ETHYNYL-BENZOIC ACID](/CAS/GIF/10602-00-3.gif)
10602-00-3
200 suppliers
$10.00/250mg