4-Fluoro-1H-pyrazole synthesis
- Product Name:4-Fluoro-1H-pyrazole
- CAS Number:35277-02-2
- Molecular formula:C3H3FN2
- Molecular Weight:86.07
761-88-6
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35277-02-2
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$8.00/100mg
Yield:35277-02-2 77%
Reaction Conditions:
with hydrazine dihydrochloride in ethanol;water at 55; for 0.5 h;
Steps:
28.C Step C: 4-fluoro-1H-pyrazole (28-d)
Hydrazine dihydro chloride (4.48g, 0.043mol) was added to a solution of (Z)-3- (dimethylamino)-2-fluoroacrylaldehyde, 28-c, (5g, 0.043mol) in 100 mL of 40%>V/V solution of EtOH in water, then the mixture was heated at 55 °C for 30 minutes. The reaction was cooled to room temperature, basified to pH=9 with a saturated solution of NaHCC"3 and the aqueous layer was extracted with Et20. The organic layers were combined and dried with Na2SC"4, the solvent was removed to give 3.6 g of the titled product, 28-d, as a yellow oil (77%)
References:
MERCK SHARP & DOHME CORP.;ZHOU, Changyou;ZOU, Wuxin;HUA, Yuxia;DANG, Qun WO2013/40790, 2013, A1 Location in patent:Page/Page column 87; 88
139680-79-8
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35277-02-2
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$8.00/100mg
853180-40-2
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35277-02-2
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38346-22-4
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35277-02-2
195 suppliers
$8.00/100mg
761-88-6
1 suppliers
inquiry
35277-02-2
195 suppliers
$8.00/100mg