4-FLUORO-2,6-BIS-HYDROXYMETHYL-PHENOL synthesis

Yield:71643-58-8 85%

Reaction Conditions:

Stage #1: formalin;4-Fluorophenolwith potassium hydroxide in lithium hydroxide monohydrate at 60; for 32 h;
Stage #2: with hydrogenchloride in dichloromethane;lithium hydroxide monohydrate; pH=3;

Steps:

2.1

1) Add 120 g of potassium hydroxide and 800 mL of water to the reaction flask.80.0 g of p-fluorophenol (compound A-1b) and 128 g of paraformaldehyde were added.The temperature was raised to 60 ° C and stirred for 32 h. The reaction solution was cooled, and dichloromethane was added.Water and hydrochloric acid were added to adjust the pH to 3, stirred, suction filtered, washed with water and dried to give Compound A-2b (104 g, yield: 85%).

References:

CN109942376,2019,A Location in patent:Paragraph 0110-0112