4-fluoro-3-methanesulfonylbenzene-1-sulfonamide synthesis

Yield:1065603-81-7 945 mg

Reaction Conditions:

with ammonium hydroxide in tetrahydrofuran;methanol;water at -50 - 0; for 3 h;

References:

Park, Cheol-Min;Bruncko, Milan;Adickes, Jessica;Bauch, Joy;Ding, Hong;Kunzer, Aaron;Marsh, Kennan C.;Nimmer, Paul;Shoemaker, Alexander R.;Song, Xiaohong;Tahir, Stephen K.;Tse, Christin;Wang, Xilu;Wendt, Michael D.;Yang, Xiufen;Zhang, Haichao;Fesik, Stephen W.;Rosenberg, Saul H.;Elmore, Steven W. [Journal of Medicinal Chemistry,2008,vol. 51,# 21,p. 6902 - 6915] Location in patent:experimental part