ChemicalBook CAS DataBase List 4-Fluoro-N,N-dimethylbenzenesulfonamide

4-Fluoro-N,N-dimethylbenzenesulfonamide synthesis

5synthesis methods

Product Name:4-Fluoro-N,N-dimethylbenzenesulfonamide
CAS Number:383-31-3
Molecular formula:C8H10FNO2S
Molecular Weight:203.23

349-88-2 Synthesis

349-88-2
304 suppliers
$6.00/5g

124-40-3
503 suppliers
$18.00/100ml

383-31-3
56 suppliers
$12.00/100mg

Yield:383-31-3 100%

Reaction Conditions:

with triethylamine in tetrahydrofuran;water at 20; for 0.333333 h;

Steps:

90.1

(1) 4-Fluoro-1-(N,N-dimethylaminosulfonyl)benzene To a solution of 4-fluorobenzenesulfonyl chloride (1.95 g, 10.0 mmol) in THF (40 mL) were added triethylamine (2.09 mL, 15.0 mmol) and 50% aqueous dimethylamine solution (1.26 mL, 14.0 mmol) at room temperature, and the solution was stirred at the same temperature for 20 minutes. The reaction mixture was diluted with ethyl acetate, and washed with water. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain 4-fluoro-1-(N,N-dimethylaminosulfonyl)benzene (2.03 g, 10.0 mmol).yield: quantitative

References:

EP1354882,2003,A1 Location in patent:Page/Page column 85

87-52-5 Synthesis