4-Fluorobenzylphosphonic acid synthesis
- Product Name:4-Fluorobenzylphosphonic acid
- CAS Number:80395-14-8
- Molecular formula:C7H8FO3P
- Molecular Weight:190.11
459-46-1
326 suppliers
$10.00/1g
80395-14-8
26 suppliers
$173.00/1g
Yield:80395-14-8 57%
Reaction Conditions:
with triethyl phosphite
Steps:
9 Diethyl, 4-fluorobenzylphosphonate (17)
EXAMPLE 9 Diethyl, 4-fluorobenzylphosphonate (17) A mixture of 4-fluorobenzyl bromide 16 (1.89 g, 10 mmol) and triethyl phosphite (1.66 g, 10 mmol) was stirred at 170° C. for 4 h. The mixture was cooled to room temperature. and the residue was subjected to flash chromatography (EtOAc: Hex, 1:4) to gave 1.4 g of 17(57%). 1H NMR (200 MHz, CDCl3): δ1.23 (t, J=7.1 Hz, 6H), 3.10 (d, J=21.4 Hz, 2H), 3.92 (q, J=7.1 Hz, 4H), 7.02 (m, 2H), 7.25 (m, 2H).
References:
US2003/149250,2003,A1
63909-58-0
90 suppliers
$22.39/1G
80395-14-8
26 suppliers
$173.00/1g