ChemicalBook CAS DataBase List 4-FORMYL-2-METHOXYPHENYL BENZOATE

4-FORMYL-2-METHOXYPHENYL BENZOATE synthesis

5synthesis methods

Product Name:4-FORMYL-2-METHOXYPHENYL BENZOATE
CAS Number:790-16-9
Molecular formula:C15H12O4
Molecular Weight:256.25

121-33-5 Synthesis

121-33-5
1107 suppliers
$9.00/1g

65-85-0 Synthesis

65-85-0
1358 suppliers
$10.00/25g

790-16-9
17 suppliers
$95.00/500mg

Yield:790-16-9 99%

Reaction Conditions:

with iodine;triethylamine;triphenylphosphine in dichloromethane at 0 - 20; for 0.333333 h;

Steps:

General procedure for the synthesis of phenolic esters

General procedure: To a solution of iodine (0.1573 g, 0.62 mmol) in CH2Cl2 (2 mL) was added with triphenylphosphine (0.1626 g, 0.62 mmol) in one portion at 0 oC. Phenol derivative (0.45mmol) and carboxylic acid (0.41 mmol) were subsequently added into the mixture,followed by addition of triethylamine (0.17 mL, 1.23 mmol) at 0 oC. The reaction mixture was allowed to warm up to room temperature and stirred until completion of thereaction (typically within 20 min). The crude mixture was concentrated under reduced pressure then purified by column chromatography (CC) using 5-10% ethyl acetate inhexane to give the desired phenolic ester product.

References:

Phakhodee, Wong;Duangkamol, Chuthamat;Pattarawarapan, Mookda [Tetrahedron Letters,2016,vol. 57,# 19,p. 2087 - 2089] Location in patent:supporting information

98-88-4 Synthesis