4-FORMYL-2-METHOXYPHENYL THIOPHENE-2-CARBOXYLATE synthesis

Yield:361472-61-9 81%

Reaction Conditions:

with triethylamine in tetrahydrofuran at 20; for 3.5 h;Reflux;

Steps:

2.2.1. General procedure for synthesis of compounds 1a-h

General procedure: Hydroxy benzaldehydes (4-hydroxybenzaldehyde, salicylalde- hyde, vanillin) (10 mmol) were dissolved in 20 ml THF separately and the solutions were then put into an ice bath. 2-furoyl chlo- ride, thiophene-2-carbonyl chloride, and tosyl chloride (10 mmol) were added to these solutions in cold. Triethylamine (11 mmol) in 20 mL THF was added to each of the solutions by dropwise and mixed for half an hour at room temperature. After undergoing re- flux for three hours, the solvent was removed under reduced pres- sure. Formed residue was washed with cold water to remove tri- ethylammonium chloride salt and recrystallized from ethanol.

References:

Tokal?, Feyzi Sinan;Taslimi, Parham;Usanmaz, Hande;Karaman, Muhammet;?endil, K?v?lc?m [Journal of Molecular Structure,2021,vol. 1231,art. no. 129666]