4-FORMYL-INDAN-1-ONE 1,2-ETHANEDIOL KETAL synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: p-TsOH / benzene / Heating
2.1: nBuLi / tetrahydrofuran / -78 °C
2.2: tetrahydrofuran / -78 - 20 °C

References:

Dinges, Juergen;Akritopoulou-Zanze, Irini;Arnold, Lee D.;Barlozzari, Teresa;Bousquet, Peter F.;Cunha, George A.;Ericsson, Anna M.;Iwasaki, Nobuhiko;Michaelides, Michael R.;Ogawa, Nobuo;Phelan, Kathleen M.;Rafferty, Paul;Sowin, Thomas J.;Stewart, Kent D.;Tokuyama, Ryukou;Xia, Zhiren;Zhang, Henry Q. [Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,# 16,p. 4371 - 4375]