4-Guanidinobenzoic acid hydrochloride synthesis
- Product Name:4-Guanidinobenzoic acid hydrochloride
- CAS Number:42823-46-1
- Molecular formula:C8H10ClN3O2
- Molecular Weight:215.64
420-04-2
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$15.00/25g
150-13-0
896 suppliers
$5.00/25g
42823-46-1
318 suppliers
$14.00/1g
Yield:42823-46-1 85%
Reaction Conditions:
with hydrogenchloride in ethanol at 50 - 78;
Steps:
1
Add 20 g of para-aminobenzoic acid to 100 ml of ethanol,Slowly add 20ml of 30% hydrochloric acid ethanol and warm to 50 ° C.Cyanamide was added dropwise 30% 40g, dropwise, the reaction 75 ± 3 5-7 hours.After the reaction was completed, the solution was concentrated to dryness under reduced pressure at 50 ° C, 50 ml of ethanol and 10 ml of 30% hydrochloric acid ethanol were added, filtered with stirring, and dried.Recrystallize with 5-10 times the volume of 20% ethanol solution to obtain pure product.The yield of the obtained 4-guanidinobenzoic acid hydrochloride was 85%.
References:
Beijing Sai Sheng Pharmaceutical Co., Ltd.;Duan Yongnian;Kong Shuangquan;Ma Biao;Song Mengwei;Ma Shengnan;Zheng Ji;Liang Dongna;Liu Jun CN110330447, 2019, A Location in patent:Paragraph 0047-0051
156-62-7
100 suppliers
$29.12/25G
150-13-0
896 suppliers
$5.00/25g
42823-46-1
318 suppliers
$14.00/1g
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1627898-15-0
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42823-46-1
318 suppliers
$14.00/1g
150-13-0
896 suppliers
$5.00/25g
42823-46-1
318 suppliers
$14.00/1g
623-00-7
468 suppliers
$6.00/10g
42823-46-1
318 suppliers
$14.00/1g