4-Heptanone synthesis
- Product Name:4-Heptanone
- CAS Number:123-19-3
- Molecular formula:C7H14O
- Molecular Weight:114.19
589-55-9
90 suppliers
$55.00/25mL
123-19-3
176 suppliers
$16.00/25mL
Yield:123-19-3 95%
Reaction Conditions:
with 3,3-dichloro-1,2-diphenylcyclopropene;dimethyl sulfoxide;triethylamine in dichloromethane at -78 - 20;Inert atmosphere;
Steps:
29 Example 29
Place a round bottom flask in a cryogenic coolant circulation tank,Add 3,3-dichloro-1,2-diphenylcyclopropene (8) (522.30 mg, 2 mmol) to the bottle under Ar protection.And 10 ml of dichloromethane,Cool the inside of the bottle to -78 ° C,Dimethyl sulfoxide (312.52 mg, 4 mmol) was added dropwise.Keep the temperature below -70 ° C, continue to stir for 30 min after the dropwise addition.Keep the temperature inside the bottle at -78 ° C - 70 ° C,4-heptanol (22) (116.19 mg, 1 mmol) was added dropwise.The temperature of the dropping process does not exceed -65 ° C, and the stirring is continued for 30 min.Add triethylamine (404.76 mg, 4 mmol),Stirring was allowed to return to room temperature and the target product selectivity was 98%.After the reaction, a saturated ammonium chloride solution was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was combined, washed with saturated NaCI.Pure 4-heptanone was obtained as a colorless liquid in a yield of 95%.
References:
CN109748782,2019,A Location in patent:Paragraph 0128; 0129
520-45-6
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$5.00/100mg
123-19-3
176 suppliers
$16.00/25mL
589-55-9
90 suppliers
$55.00/25mL
71-36-3
1043 suppliers
$14.00/25mL
110-62-3
248 suppliers
$13.44/25ML
123-19-3
176 suppliers
$16.00/25mL
71-36-3
1043 suppliers
$14.00/25mL
106-98-9
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$10.00/25g
110-62-3
248 suppliers
$13.44/25ML
123-19-3
176 suppliers
$16.00/25mL
71-36-3
1043 suppliers
$14.00/25mL
110-62-3
248 suppliers
$13.44/25ML
123-19-3
176 suppliers
$16.00/25mL
109-21-7
245 suppliers
$19.00/25mL